Friday, June 27, 2014

Is it time to throw in the towel on traditional antidepressants?

Is it time to throw in the towel on traditional antidepressants?  They do not appear to work say better than exercise or any other mildly psychotropic pill if a doctor made you take it daily and follow up, for example, I imagine under those circumstances a low dose coffee pill, sugar pill, or benadryl would work as well or better than most antidepressants.  In fact, it seems like the best results come from antidepressants that appear to do almost nothing, like escitalopram.

New rapid-acting antidepressants are a different story.  They have actually been here for many decades, just not used for depression (ketamine, dxm, scopalamine).  Without exception, they can cause intoxication and mess with memory, but some newer theories suggest that effect is almost central, if you can cause it to be less acute and get the same antidepressant effect, or block the experience of delirium or intoxication with the same blocking and synaptagenesis, one can get the results without initial intoxication, which typically is short-lasting in any case.  Of course, one would not take such things for a bad mood or mild depression since there are unknown risks, but for depression so bad it threatens one's life, it's certainly better than the alternative.

What do you think?

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